MSM and Vit C for bone healing
- Chevelle Lolli's Lollies
- Aug 16
- 3 min read
Curious if you can support the bone healing and repair process?
Here a few a few interesting peer reviewed studies.
Emerging Science:
Animal studies reveal that MSM enhances bone-forming cell activity and helps preserve bone mass and quality under stress. Vitamin C has been shown to speed fracture healing and boost collagen production, crucial for bone strength. While research on their combined effects in dogs is still developing, their complementary antioxidant and tissue-support roles suggest a valuable pairing for canine surgical recovery and bone health.
Scientific Findings: MSM, Vitamin C & Bone Health
1. MSM Enhances Bone Formation and Reduces Oxidative Stress
In vivo evidence (mandible model, mice): MSM injection induced osteoblast formation—cells responsible for building bone—and resulted in increased bone formation in the mandible region, showing direct bone healing potential.
Age-induced bone loss model: In geriatric mice, MSM supplementation improved bone mass, microstructure, and load-bearing strength. This effect was attributed to its antioxidant ability to mitigate oxidative-stress-induced bone resorption.
2. Vitamin C Accelerates Fracture Healing and Collagen Production
Systematic reviews (animal and human preclinical studies): Vitamin C supplementation accelerated bone regeneration after fractures, enhanced type I collagen synthesis, and reduced oxidative stress—though human clinical evidence is still sparse.
Another systematic analysis on bone healing: Confirms vitamin C boosts osteoblastic proliferation, differentiation, and antioxidant protection in animal models of bone regeneration.
3. Synergy and Supportive Mechanisms
MSM as an antioxidant complement: MSM’s ability to buffer oxidative stress, combined with vitamin C's bone-supportive action, makes their combined use potentially advantageous in bone healing scenarios. This is especially relevant in settings of oxidative damage or age-related bone degeneration.
MSM absorption benefit: Vitamin C improves MSM absorption and both share roles in collagen synthesis and antioxidant function—making them a practical duo for skeletal and connective tissue repair.
Summary Table: Key Findings
Compound Benefit to Bone Health & Tissue Repair
MSM - Promotes osteoblast function, supports bone formation, mitigates oxidative stress
Vitamin C - Accelerates fracture healing, enhances collagen synthesis, reduces oxidative stress
Combination MSM and Vit C Synergistic roles: antioxidant protection, improved absorption, collagen support
Lolli’s Lollies – Supporting Healing Naturally
At Lolli’s Lollies, we believe recovery and long-term health should be supported with natural, evidence-based ingredients. Our flagship recovery blend, The Regen Remedy, combines Grass-Fed Bovine Collagen Peptides, Rosehip Granules, and MSM to promote tissue repair, reduce inflammation, and support joint strength during healing. This carefully balanced formula is designed to complement your dog’s diet pre- and post-surgery, making recovery smoother and more comfortable.
For pet parents who prefer targeted support, we also offer single-ingredient supplements like MSM and Grass-Fed Bovine Collagen Peptides, so you can personalise your dog’s care with trusted, high-quality options. Each product is sourced with purity and effectiveness in mind, ensuring your dog gets the very best in natural healing support.
At Lolli’s Lollies, every supplement is crafted with a dedication to quality, safety, and holistic well-being—because your dog deserves the strongest foundation for recovery and a vibrant, active life.
Further Reading
MSM & Bone Health
1. Kim, B.-J., et al. (2021). Methylsulfonylmethane Increases Osteoblast Differentiation via the Wnt/β-Catenin Signaling Pathway in Mice. Frontiers in Physiology, 12:708905.
2. Ma, X., et al. (2025). Methylsulfonylmethane Ameliorates Age-Induced Bone Loss by Attenuating Oxidative Stress. Nutrients, 17(3):501.
Vitamin C & Bone Healing
3. Molnar, V., et al. (2018). The Effect of Vitamin C on Bone Healing: A Systematic Review. Orthopaedic Journal of Sports Medicine, 6(10):2325967118804544.
4. Yilmaz, C., et al. (2018). The Effect of Vitamin C on Fracture Healing in Experimental Animal Models. EFORT Open Reviews, 3(9): 558–564.
5. Chhina, H., et al. (2022). The Role of Vitamin C in Bone Healing: A Systematic Review. European Journal of Orthopaedic Surgery & Traumatology, 32(2): 247–257.
6. The Regen Remedy by Lolli's Lollies
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